Tylenol Extra Strength Cold and Sinus is made with a powerful decongestant and pain reliever to give you long lasting relief from the toughest cold and sinusitis symptoms. The Daytime tablets provide quick, effective relief from nasal congestion, sinus pain, headache and fever to get you through the day. The nighttime tablets give you extra comfort by relieving you from a bothersome runny nose and constant sneezing. Daytime relieves: Nasal congestion Sinus pain and pressure Headache and fever Nighttime Relieves: Nasal congestion Sinus pain and pressure Headache and fever Runny nose/sneezing Contains acetaminophen and other ingredients.