Anusol Plus Ointment for fast and long-lasting relief Get comfortable again with Anusol Plus Ointment a soothing ointment that targets the pain, itching and burning symptoms of hemorrhoids with an added anesthetic for extra pain relief. It contains a gentle astringent to reduce swelling, giving your hemorrhoids a better chance to heal. Anusol is the #1 pain-relief brand recommended by doctors and pharmacists for internal and external hemorrhoids.